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George W. Booz Author information Copyright and License information Disclaimer The publisher's final edited version of this article is available at Free Radic Biol Med See other articles in PMC that cite the published article. Go to: Abstract Oxidative stress with reactive oxygen species generation is a key weapon in the arsenal of the immune system for fighting invading pathogens and to initiate tissue repair. If excessive or unresolved, however, immune-related oxidative stress can initiate further increasing levels of oxidative stress that cause organ damage and dysfunction. Targeting oxidative stress in these various diseases therapeutically has proven more problematic than first anticipated given the complexities...

Cannabidiol rather than Cannabis sativa extracts inhibit cell growth and induce apoptosis in cervical cancer cells Sindiswa T. Lukhele and Lesetja R. Motadi Author information Article notes Copyright and License information Disclaimer This article has been cited by other articles in PMC. Associated Data Data Availability Statement Go to: Abstract Background Cervical cancer remains a global health related issue among females of Sub-Saharan Africa, with over half a million new cases reported each year. Different therapeutic regimens have been suggested in various regions of Africa, however, over a quarter of a million women die of cervical cancer, annually. This makes it the most lethal cancer amongst black women and...

Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration Shuso Takeda,a Shunsuke Okajima,a Hiroko Miyoshi,a Kazutaka Yoshida,a Yoshiko Okamoto,a Tomoko Okada,b Toshiaki Amamoto,c Kazuhito Watanabe,d Curtis J. Omiecinski,e and Hironori Aramakia,* Author information Copyright and License information Disclaimer The publisher's final edited version of this article is available at Toxicol Lett See other articles in PMC that cite the published article. Go to: Abstract Cannabidiol (CBD), a major non-psychotropic constituent of fiber-type cannabis plant, has been reported to possess diverse biological activities, including anti-proliferative effect on cancer cells. Although CBD is obtained from non-enzymatic decarboxylation of its parent molecule, cannabidiolic acid (CBDA), few studies have investigated whether...

Oleksandrum/Adobe StockDr. Mechoulam Does It AgainIn an exciting mainstream media report, NBC news highlighted a groundbreaking new development from the lab of Dr. Raphael Mechoulam, the godfather of cannabis chemistry: cannabinoid acids.September 27, 2019 Andrea Sparr-JaswaBreaking News International Medical Cannabis NewsIn an exciting mainstream media report yesterday, NBC News highlighted a groundbreaking new development from the lab of Dr. Raphael Mechoulam, the godfather of cannabis chemistry: cannabinoid acids.Dr. Mechoulam, an organic chemist and professor of medicinal chemistry based at the Hebrew University in Jerusalem, led the first team of researchers to discover and synthesize the two primary medicinal compounds in...